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Hydrogenated Cannabinoid Potency: S vs R Diastereomer

Updated: Nov 9, 2023

While hydrogenated like HHC, H4CBD, HHCo, and HHC-P are analogs of THC, there is still more than one diastereomer of each and it’s important to consider them when looking at potency.


What is a diastereomer?

Diastereomers are different versions of the same molecule that have distinct spatial arrangements of their atoms. They are not mirror images of each other, unlike enantiomers. Diastereomers can have different chemical properties and behaviors due to their unique structures.


What are the important diastereomers when it comes to hydrogenated noids?

For the hydrogenated noids, the important diastereomers to know about are the S diastereomer and the R diastereomer.


It was debated for some time, but it seems to have come to a consensus now, the R diastereomer is the FAR more potent one.


What do I look for on the COA?

When you open the COA you'll usually see the R% on the top next to the total cannabinoids, but to find both the R and S percentages you can look at the cannabinoid content for the following.

9R-(noid here):

9S-(noid here):


Below is an example of a good H4CBD COA that shows S and R%. I have highlighted the R% so you know what to look for when you are shopping.

You can see that the total cannabinoid % is indeed not the only number you need to look at. The R diastereomer is 85% and the S is at 13%.


Are there any tricks vendors use on the COAs to look out for?

One thing to keep in mind is that some less reputable brands have been known to show the S% at the top of the COA instead of the R%. They will do this when the S value is higher than the R value. Many people who do not know the difference will just assume the S value is the one to pay attention to because it is highlighted at the top.


Hopefully this answers your questions about the S and R diastereomers and their effect on potency! If you want more info or know of something more leave a message in chat!


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